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Lau 4,5,6,7 , Kenneth K. Leung 4 , Adrienne Y. Chan 4,5,6,10 , Celine S. Chui 6,11,12 , Ian C. Wong 4,5,6,7,13 , Ju-Young Shin 1,2, Background Polypharmacy among older people represents a global challenge due to its association with adverse drug events. The reported prevalence of polypharmacy varies widely across countries, and is particularly high in Asian countries.

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Phospholipase D PLD is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The inhibitor enhanced apoptosis in colorectal cancer CRC cells but not in normal colonic cells, and in vitro cardiotoxicity was not observed. In cancer, therapeutic engagement of immunogenic cell death ICD leads to more effective responses by eliciting the antitumor immunity of T cells. PLD1 inhibition subsequently enhanced the phagocytosis of cancer cells by macrophages through the surface expression of costimulatory molecules; as a result, the cancer cells were more susceptible to cytotoxic T-cell-mediated killing. Moreover, PLD1 inhibition attenuated colitis-associated CRC and orthotopically injected tumors, probably by controlling multiple pathways, including Wnt signaling, phagocytosis checkpoints, and immune signaling. Furthermore, combination therapy with a PLD1 inhibitor and an anti-PD-L1 antibody further enhanced tumor regression via immune activation in the tumor environment. Collectively, in this study, PLD1 was identified as a critical regulator of the tumor microenvironment in colorectal cancer, suggesting the potential of PLD1 inhibitors for cancer immunotherapy based on ICD and immune activation.

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Lee was in a relationship with Jun Hyun-moo , a former announcer turned broadcast personality and host. This biographical article about a South Korean personality is a stub. You can help Wikipedia by expanding it. This Asian biographical article related to television is a stub. Contents move to sidebar hide. Article Talk.

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Phospholipase D PLD is a potential therapeutic target against cancer. Tuesday 23 January Wednesday 8 November Wednesday 18 October Thursday 21 December However, the contribution of PLD inhibition to the antitumor response remains unknown. Don't want to see ads? Friday 9 February Wednesday 20 September Tuesday 2 January Thursday 11 January In cancer, therapeutic engagement of immunogenic cell death ICD leads to more effective responses by eliciting the antitumor immunity of T cells.

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Do you know a YouTube video for this track? View all trending tracks. Thursday 11 January We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. Wednesday 8 November Saturday 6 January Start the wiki. Friday 26 January Tuesday 7 November Friday 17 November Sunday 5 November