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This medicine is known as sertraline. Exercise has many benefits for older adults and can help you to live a longer and healthier life.

Go PRO to access past versions. Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancy. Risk Summary Based on data from published observational studies, exposure to SSRIs, particularly in the month before delivery, has been associated with less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions 5. Overall, available published epidemiologic studies of pregnant women exposed to sertraline in the first trimester suggest no difference in major birth defect risk compared to the background rate for major birth defects in comparator populations. Some studies have reported increases for specific major birth defects; however, these study results are inconclusive [See Data].

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If you are a consumer or patient please visit this version. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of Sertraline Hydrochloride Tablets or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Sertraline Hydrochloride Tablets are not approved for the treatment of major depressive disorder in pediatric patients. Sertraline is a selective serotonin reuptake inhibitor SSRI for oral administration. It has a molecular weight of Sertraline hydrochloride has the following chemical name: 1S-cis 3,4-dichlorophenyl -1,2,3,4-tetrahydro-N-methylnaphthalenamine hydrochloride. Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. The mechanism of action of sertraline is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin 5HT.

The results suggest that the use of sertraline in patients with liver disease must be approached with caution. In managing overdosage, consider the possibility of multiple drug involvement. General supportive and symptomatic measures are also recommended.

If you are a consumer or patient please visit this version. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of Sertraline hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.

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Specifically, pharmacists have access to drug information from a variety of resources, including print publications, subscription-based electronic databases e. Thus, when searching for drug information, many times the problem facing a pharmacist is not a lack of resources, but rather too many resources from which to choose. Its availability, ease of use, contents, and legal weight make the PI the resource that should often be the starting point when initiating a search for drug information. The Fair Packaging and Labeling Act requires all consumer products in interstate commerce to be honestly and informatively labeled, with the FDA enforcing these provisions on foods, drugs, cosmetics, and medical devices. The regulations governing labeling of OTC medications, formalized in , are different. When the format of the PI was amended in , it was the first such change since , when a standard format was first promulgated by the FDA.

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Urinary System Disorders — Infrequent: micturition frequency, polyuria, urinary retention, dysuria, nocturia, urinary incontinence; Rare: cystitis, oliguria, pyelonephritis, hematuria, renal pain, strangury. Suicidal thoughts or actions: Sertraline tablets and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. The risk of using sertraline in combination with other CNS active drugs has not been systematically evaluated. Sertraline may be administered either continuously every day throughout the menstrual cycle or intermittently only during the luteal phase of the menstrual cycle, i. Drugs that Interfere with Hemostasis antiplatelet agents and anticoagulants. Whether any of the symptoms described above represent such a conversion is unknown. The antidepressant action of sertraline hydrochloride in hospitalized depressed patients has not been adequately studied. No suicides occurred in any of the pediatric trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The physician may consider tapering sertraline in the third trimester. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. Hello, Okiemo! Initial Treatment.

This medicine is known as sertraline. Exercise has many benefits for older adults and can help you to live a longer and healthier life.

There is currently no corroborative evidence regarding the risk for PPHN following exposure to SSRIs in pregnancy; this is the first study that has investigated the potential risk. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness , hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well as for other indications, both psychiatric and nonpsychiatric. Seizures or convulsions Manic episodes: greatly increased energy severe trouble sleeping racing thoughts reckless behavior unusually grand ideas excessive happiness or irritability talking more or faster than usual Changes in appetite or weight. There may be treatments your healthcare provider can suggest. Consequently, a dose of 50 mg, administered once daily, is recommended as the initial therapeutic dose. Study 3 was not readily interpretable regarding a dose response relationship for effectiveness. The effect of sertraline on valproate levels has not been evaluated in clinical trials. The clinical significance of this apparent gender interaction is unknown at this time. Patients should be periodically reassessed to determine the need for maintenance treatment. Hypertension most commonly seen, but rarely can see hypotension alone or with co-ingestants including alcohol.