Cus-1811

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Federal government websites often end in. The site is secure. Chronic ulcerative stomatitis CUS is a rarely reported disease affecting the oral cavity, most often affecting middle-aged Caucasian females. The aim of the present study is to present the diagnosis, differentiation, and interdisciplinary treatment of this rare disease. CUS is characterized by the presence of an oral erosive or ulcerative lesion. Clinically, the lesions presented in oral mucosa might resemble an erosive form of oral lichen planus, whereas gingival lesions seem to be similar to desquamative gingivitis related to dermatological diseases manifested in the oral cavity. Patients often report subjective symptoms related to oral mucosa and general symptoms.

Cus-1811

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The histopathological presentation of CUS is often non-specific.

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Cus-1811

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If you have trouble using one of the following, please give us a call. Oral Pathol. Those conditions also commonly involve gingival bleeding and hypertrophic gingivitis [ 49 , 55 ]. CUS is characterized by the presence of an oral erosive or ulcerative lesion. Clinical symptoms Diagnostic tests Treatment Azzi et al. The structural similarity of the p63 and p73 proteins to the p53 proteins applies to the N-terminal transactivation domain, a central DNA-binding protein, and an oligomerization domain close to the C-terminus [ 6 , 16 , 17 , 18 ]. All Rights Reserved. Fourie J. Diebold S. According to conducted research, all patients presented at least one clinically evident CUS symptom, and in most of the cases, more than one clinical sign was observed [ 3 , 6 , 7 , 10 , 12 , 20 , 25 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Among patients with clinically observed long-lasting oral erosions and ulcerations, the DIF analysis should be conducted in order to diagnose CUS [ 6 ]. The first to describe CUS as a distinct entity were Parodi et al.

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Histopathological presentation of CUS is often non-specific and includes sub-epithelial separation from underlying connective tissue, atrophic epithelium, and inflammatory infiltrate with an increased number of plasma cells and lymphocytes. Mass Flow Controllers. Oral Radiol. In addition, DIF combined with histopathology might complete the clinical and histological examination in the diagnosis of a variety of other dermatological diseases, which include connective tissue disorders, vasculitides, and conditions, such as lichen planus or others. Indian J. Adblocker plugins can interfere with the Adaptive streaming APIs. MKS Instruments. Low doses of antimalarial drugs combined with corticosteroids administrated for a prolonged time. Conclusions Chronic ulcerative stomatitis CUS manifests as non-healing, erosive, or ulcerative lesions in the oral cavity and is an often-misdiagnosed disease due to both its clinical and histological resemblance to other oral mucosa conditions. Ko et al. Sign Up Free!