Free radic biol med

Elsevier Inc. How to publish in this journal. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles.

Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Redox Biology and Medicine. The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals , reactive species, oxidants and antioxidants. This article about a biochemistry journal is a stub. You can help Wikipedia by expanding it. See tips for writing articles about academic journals. Further suggestions might be found on the article's talk page. Contents move to sidebar hide.

Free radic biol med

.

Download as PDF Printable version.

.

Cardiovascular diseases CVD , including ischemic heart diseases and cerebrovascular diseases, are the leading causes of morbidity and mortality worldwide. Atherosclerosis is the major underlying factor for most CVD. It is well-established that oxidative stress and inflammation are two major mechanisms leading to atherosclerosis. Under oxidative stress, polyunsaturated fatty acids PUFA -containing phospholipids and cholesterol esters in cellular membrane and lipoproteins can be readily oxidized through a free radical-induced lipid peroxidation LPO process to form a complex mixture of oxidation products. Overwhelming evidence demonstrates that these oxidized lipids are actively involved in the inflammatory responses in atherosclerosis by interacting with immune cells such as macrophages and endothelial cells. In addition to lipid lowering in the prevention and treatment of atherosclerotic CVD, targeting chronic inflammation has been entering the medical realm. Clinical trials are under way to lower the lipoprotein a Lp a and its associated oxidized phospholipids, which will provide clinical evidence that targeting inflammation caused by oxidized lipids is a viable approach for CVD.

Free radic biol med

The discovery of vitamin E will have its th anniversary in , but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat-soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the s. In the same years the cytochrome P dependent metabolism of vitamin E was characterized and a first series of studies on short-chain carboxyethyl metabolites in the s paved the way to the hypothesis of a biological role for this metabolism alternative to vitamin E catabolism. Recent findings are consistent with gene regulation and homeostatic roles of these metabolites in different experimental models, such as inflammatory, neuronal and hepatic cells, and in vivo in animal models of acute inflammation. Molecular mechanisms underlying these responses are under investigation in several laboratories and side-glances to research on other fat soluble vitamins may help to move faster in this direction. Other emerging aspects presented in this review paper include novel insights on the mechanisms of reduction of the cardiovascular risk, immunomodulation and antiallergic effects, neuroprotection properties in models of glutamate excitotoxicity and spino-cerebellar damage, hepatoprotection and prevention of liver toxicity by different causes and even therapeutic applications in non-alcoholic steatohepatitis. We here discuss these topics with the aim of stimulating the interest of the scientific community and further research activities that may help to celebrate this anniversary of vitamin E with an in-depth knowledge of its action as vitamin. Abstract The discovery of vitamin E will have its th anniversary in , but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health.

Synonym fully

Hidden categories: Articles lacking sources from October All articles lacking sources Articles with short description Short description is different from Wikidata Biweekly journals infobox Articles with outdated impact factors from Pages using infobox journal with unknown parameters All stub articles. This article does not cite any sources. The purpose is to have a forum in which general doubts about the processes of publication in the journal, experiences and other issues derived from the publication of papers are resolved. This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Unsourced material may be challenged and removed. Read Edit View history. Citations per document. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Download as PDF Printable version. Year SJR 1. Elsevier Netherlands. Toggle limited content width. Q1 green comprises the quarter of the journals with the highest values, Q2 yellow the second highest values, Q3 orange the third highest values and Q4 red the lowest values. The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals , reactive species, oxidants and antioxidants. For topics on particular articles, maintain the dialogue through the usual channels with your editor.

Federal government websites often end in. The site is secure.

The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals , reactive species, oxidants and antioxidants. Read Edit View history. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. Information Homepage How to publish in this journal. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. See tips for writing articles about academic journals. It is based on the idea that 'all citations are not created equal'. Scope Free Radical Biology and Medicine is the premier forum for publishing groundbreaking research in the redox biology of both health and disease. International Collaboration accounts for the articles that have been produced by researchers from several countries. For topics on particular articles, maintain the dialogue through the usual channels with your editor. Publisher Elsevier Inc.