Free radic res

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Free Radical Research , formerly Free Radical Research Communications , is an academic journal that publishes research papers, hypotheses, and reviews on free radicals , redox signaling , antioxidants , and oxidative damage. It is published by Informa Healthcare. Free Radical Research publishes 12 issues per year in simultaneous print and online editions. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools.

Free radic res

Federal government websites often end in. The site is secure. In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases. The recent growth in the knowledge of free radicals and reactive oxygen species ROS in biology is producing a medical revolution that promises a new age of health and disease management. Free radicals and antioxidants have become commonly used terms in modern discussions of disease mechanisms. A free radical can be defined as any molecular species capable of independent existence that contains an unpaired electron in an atomic orbital. The presence of an unpaired electron results in certain common properties that are shared by most radicals.

Pezzuto, J. Cell Signal. Kwee, and S.

Informa Healthcare. How to publish in this journal. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Q1 green comprises the quarter of the journals with the highest values, Q2 yellow the second highest values, Q3 orange the third highest values and Q4 red the lowest values. The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. It is based on the idea that 'all citations are not created equal'.

Acute kidney injury AKI is a major kidney disease associated with poor clinical outcomes. Oxidative stress is predominantly involved in the pathogenesis of AKI. Autophagy and the Keap1-Nrf2 signalling pathway are both involved in the oxidative-stress response. However, the cross talk between these two pathways in AKI remains unknown. Here, we found that autophagy is upregulated during cisplatin-induced AKI. In contrast with previous studies, we observed a marked increase in p We also found that p62 knockdown reduces autophagosome formation and the expression of LC3II. To explore the cross talk between p62 and the Keap1-Nrf2 signalling pathway, HK-2 cells were transfected with siRNA targeting Nrf2, and we found that Nrf2 knockdown significantly reduced cisplatin-induced p62 expression.

Free radic res

Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 CoQ10 are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an important antioxidant.

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Some of the nutritional antioxidants will retard the aging process and prevent disease. Oxidative stress and lung inflammation in airways disease. A review. It has been suggested that 8-hydroxydeoxyguanosine can be used as biological marker for oxidative stress. Trends Plant Sci. At low or moderate concentrations, ROS and RNS are necessary for the maturation process of cellular structures and can act as weapons for the host defense system. These compounds have been widely uses as antioxidants in food industry, cosmetics, and therapeutic industry. Ashton, and S. How to publish in this journal. Cites Year Value External Cites per document 2.

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro.

Goetzl, E. Speizer, and W. Dyer, S. Gey, K. Pryor, W. The site is secure. Jialal, I. Radicals is mainly addition to double bond of pyrimidine bases and abstraction of hydrogen from the sugar moiety resulting in chain reaction of DNA. Omega-3 and omega-6 fatty acids. Kozumbo, W. Google Scholar Gaston, B. Stephens, N. Brynes, R. Federal government websites often end in. Oxidative stress: Oxidants and antioxidants.