J exp med

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Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. The paramount objective of WJEM is to showcase and promote distinguished research in the field of experimental medicine, to help advance development of this field. Advanced Search. Risk factors for hydroxychloroquine-induced arrhythmia.

J exp med

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Although the journal was adopted by the Rockefeller Institute as a venue for publication of the institute's own research, it also accepted submissions from outside. Even in the early years, more than half of the papers published in the journal came from external labs.

This manuscript j exp med that in the absence of cholesterol hydroxylase Ch25h and the resultant reduction in hydroxycholesterol, age-dependent neuroinflammation and neurodegeneration are strikingly reduced in a mouse model of tauopathy. Rockefeller University Press United States. View This Issue.

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Adeline E. Walsh , John R. Lukens; Engineering mighty microglia. J Exp Med 6 March ; 3 : e Defective microglial responses underlie many neurological disorders. Recent efforts to swap out dysfunctional microglia with optimized replacements have been derailed by safety issues and transplantation inefficiencies. In this issue, Chadarevian et al. Chadarevian et al.

J exp med

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions. Abstract Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. Publication types Research Support, N.

Saad al ghamdi

Accessed February 23, Contents move to sidebar hide. Research on nanosciences involvement in pharmaceutical education should be reinforced. Contents Volume 13 Issue 5 December 20, Mechanism for the peripheral activity of anti-PD Impact factor. Sign In. Intrathecal VEGF-C pretreatment promotes lymphatic drainage of brain-derived fluids and improves neurological outcomes after ischemic stroke via reduced microglia-mediated neuroinflammation and increased BDNF signaling. In vitro study on the transmission of multidrug-resistant bacteria from textiles to pig skin. March 05 March 07 World J Exp Med 13 5 : The study shows that rare, damaging variants in lupus patients enable breach of B cell immune tolerance checkpoints and suggests involvement for dysregulated IL-4R signaling and BAFF-R expression. Lymph node microenvironments support Th2 differentiation.

She has been a professional editor since when she joined Journal of Experimental Medicine as a scientific editor. She then pursued her postdoctoral research with Robert Darnell at The Rockefeller University, focusing on RNA-protein crosstalk in neurological diseases.

Manage Email Alerts. IL promotes skin autoinflammation. Accessed February 23, March 07 In this issue of JEM , Boisserand et al. All rights reserved. Special Collections. In vitro study on the transmission of multidrug-resistant bacteria from textiles to pig skin. Intrathecal VEGF-C pretreatment promotes lymphatic drainage of brain-derived fluids and improves neurological outcomes after ischemic stroke via reduced microglia-mediated neuroinflammation and increased BDNF signaling. Cellular senescence: Neither irreversible nor reversible.