Lipoprotein lipase

It is a water-soluble enzyme lipoprotein lipase hydrolyzes triglycerides in lipoproteinssuch as those found in chylomicrons and very low-density lipoproteins VLDLinto two free fatty acids and one monoacylglycerol molecule:.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Lipoprotein lipase LPL is an extracellular enzyme on the vascular endothelial surface that degrades circulating triglycerides in the bloodstream.

Lipoprotein lipase

Lipoprotein lipase LPL catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. Furthermore, abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease, and dyslipidaemia associated with diabetes, insulin resistance, and infection. Advances have also been made in relating the various domains in the protein to different functions, and in understanding the mechanisms that are responsible for the changes in LPL expression seen in response to nutritional and other physiological changes, and during disease. This review summarises recent findings in relation to the structure, function, and regulation of LPL along with its important role in disease. Abstract Lipoprotein lipase LPL catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Publication types Research Support, Non-U. Gov't Review. Substances Lipoproteins Lipoprotein Lipase.

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Official websites use. Share sensitive information only on official, secure websites. Familial lipoprotein lipase deficiency is a group of rare genetic disorders in which a person lacks a protein needed to break down fat molecules. The disorder causes a large amount of fat to build up in the blood. Familial lipoprotein lipase deficiency is caused by a defective gene that is passed down through families.

Federal government websites often end in. The site is secure. Lipoprotein lipase LPL is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and VLDL. Since LPL was initially discovered in the s, its biology and pathophysiological significance have been well characterized and documented. LPL was first discovered in by Dr. Edward Korn in [ 2 , 3 ].

Lipoprotein lipase

Official websites use. Share sensitive information only on official, secure websites. The LPL gene provides instructions for making an enzyme called lipoprotein lipase. This enzyme is found primarily on the surface of cells that line tiny blood vessels capillaries within muscles and in fatty adipose tissue.

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Fibrates are usually combined with other cholesterol-lowering treatments as they increase low-density lipoproteins LDL. Molecular Level The structure of lipoprotein lipase is similar to the enzymes in the lipase family and comprises two distinct regions. In other cases, the enzyme is impaired, resulting in increased fat levels, a condition called hyperlipidemia. Ann Genet. After translation, the newly synthesized protein is glycosylated in the endoplasmic reticulum. Updated by: Sandeep K. J Lipid Res. Related MedlinePlus Health Topics. Fibrates, such as fenofibrate, bezafibrate, and gemfibrozil, work by activating peroxisome proliferator-activated receptor alpha PPAR-alpha and upregulating lipoprotein lipase. Genetic tests may be done. Foam cells also form when macrophages incorporate oxidized LDL via their scavenger receptor in the vascular endothelium. Download as PDF Printable version. Disclosure: McDamian Anoruo declares no relevant financial relationships with ineligible companies.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure.

Lipoprotein disorders and cardiovascular disease. Biochim Biophys Acta. Substances Lipoproteins Lipoprotein Lipase. Fat particles called chylomicrons build up in the blood. British Journal of Haematology. J Mol Med Berl. Click on genes, proteins and metabolites below to link to respective articles. Modified gene transcription leads to increased lipoprotein lipase activity. Lipoprotein lipase breaks down triglycerides carried by two different types of lipoproteins, which bring fat to the bloodstream from different organs. Treatment aims to control the symptoms and blood triglyceride levels with a very low-fat diet. Bibcode : PNAS.. Review [Lipoprotein lipase].