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Federal government websites often end in. The site is secure. Language: English French. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission. Although most gastroenterologists are very familiar with these drugs, the interest in these drugs has undergone a resurgence, with new preparations offering convenience and high dosage, while preserving their customary safety. New dosage regimens are likely to become standard practice in the near future. There is also considerable interest in chemoprevention of colorectal cancer in the context of inflammatory bowel disease, and the role of long-term maintenance therapy with 5-ASAs in achieving such chemoprevention. A mechanism of action for such chemoprevention has been provided by the agonism of the peroxisome proliferator-activated receptor-gamma by 5-ASA, which unifies its efficacy as an anti-inflammatory and chemopreventive agent. Intestinal inflammation can result in bleeding and anemia, perforation with abscess or fistula formation, or subsequent fibrosis with intestinal obstruction 1.

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Mesalazine , also known as mesalamine or 5-aminosalicylic acid 5-ASA , is a medication used to treat inflammatory bowel disease , including ulcerative colitis and Crohn's disease. Common side-effects include headache, nausea, abdominal pain, and fever. Mesalazine was approved for medical use in the United States in It is used to treat inflammatory bowel disease , including ulcerative colitis and Crohn's disease effective only in colonic diseases. In Germany introduced guidance to use mesalamine to treat acute uncomplicated diverticulitis. Most often reported side-effects are gastrointestinal GI but may also include headache , including: nausea, diarrhea, and abdominal pain. Very rarely, use of mesalazine has been associated with an exacerbation of the symptoms of colitis , Stevens Johnson syndrome , and erythema multiforme. There is no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk.

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M esalazine is an anti-inflammatory medicine used to treat a type of bowel disease known as ulcerative colitis. It helps to reduce symptoms such as diarrhea, bleeding and stomach pain by reducing inflammation in the bowel.

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