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The current guidelines have been developed to support healthcare professionals with the diagnosis and management of patients with infective endocarditis, an infrequent but oftentimes fatal disease that can present with multiple different clinical scenarios. Since then there have been multiple developments in the care of patients with infective endocarditis including refinements of the indications for antibiotic prophylaxis, improvements in diagnostic capabilities, establishment of Endocarditis Teams and Heart Valve Centers, identification of patients eligible for outpatient antibiotic therapy, diagnosis and risk-stratification of patients suffering complications of endocarditis in particular, stroke , management of patients with transcatheter heart valve- and cardiac implantable electronic device-associated infective endocarditis, and patient-centered care during the acute and follow up phases of this challenging disease. In addition, the version of the Guidelines includes a new diagnostic algorithm, which will be particularly helpful in correctly classifying patients. The current document should serve as a guide for clinicians involved in the diagnosis and management of infective endocarditis patients and should lead to improved outcomes for this serious disease. Guidelines and related materials are for use by individuals for personal or educational purposes. No commercial use is allowed. Re-use permission must be correctly obtained from the publisher. ESC Guidelines are protected by copyright. Any use of ESC Guidelines in software tools, generative AI models, computational models, or algorithms in which ESC Guideline content is included, cited, or transformed in any way requires a formal license agreement.

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The present guideline has been developed to support healthcare professionals in the diagnosis and management of patients presenting with acute coronary syndrome ACS. For the first time, the present guideline presents recommendations for management of patients across the entire spectrum of ACS in one document. There have been numerous developments in the diagnosis and treatment of patients with ACS in the intervening years, which are reflected in this up-to-date guideline.

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