Ondansetron drug interactions

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Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally.

Ondansetron drug interactions

Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old. To make sure ondansetron is safe for you, tell your doctor if you have:. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria PKU. Get emergency medical help if you have rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Both Ondansetron and Sunitinib prolong the QT interval. Knowing how anything you put into your body can interact with another product is important.

Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. The purpose of this study was to evaluate the potential pharmacokinetic interactions between ondansetron and high-dose alkylating agent chemotherapy. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. All patients received lorazepam every 4 h. A group of 75 matched historical controls had received a continuous infusion of prochlorperazine with lorazepam. Pharmacokinetic monitoring of each drug used in the high-dose chemotherapy regimen was conducted.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally.

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Contact your doctor right away if you have any changes to your heart rhythm. Clearance ranges from 0. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ondansetron in the elderly. Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Both Ondansetron and Almotriptan can increase the risk of serotonin syndrome. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. Similar articles in PubMed. Pharmacists should ensure proper dose, perform medication reconciliation and consult prescribers about any concerns. Terms and conditions of use. Also tell them about any supplements you take.

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Toenail Fungus: Fact vs Myth Module. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. Take this medicine only as directed by your doctor. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. It is not advisable to combine medications that increase serotonin simultaneously due to the risk of serotonin syndrome and toxicity. Ondansetron Zofran. Future randomized studies are needed to delineate the effect of ondansetron on the disposition of the active cyclophosphamide metabolites so that clinical implications can be addressed. N Engl J Med. Read more. Alexandria Griddine ; Jeffrey S. Objectives: Identify the antiemetic mechanism of action of ondansetron. Review Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis. Off-label use for the prevention of nausea and vomiting associated with pregnancy. Mizolastine is predicted to increase the risk of QT-prolongation when given with Ondansetron.