Peroxynitrite

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Peroxynitrite can be prepared by the reaction of superoxide with nitric oxide : [1] [2] [3]. It is prepared by the reaction of hydrogen peroxide with nitrite : [4]. It is reactive toward DNA and proteins. It is these radicals carbonate radical and nitrogen dioxide that are believed to cause peroxynitrite-related cellular damage. Its conjugate acid peroxynitrous acid is highly reactive, although peroxynitrite is stable in basic solutions. Contents move to sidebar hide. Article Talk.

Peroxynitrite

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Recent evidence points to cytochrome c as an peroxynitrite heme peroxidase after a conformational change triggered by binding to cardiolipin and indicates that this process is related to apoptotic signaling The complete catalytic cycle to restore peroxiredoxin to the resting state is analyzed elsewhere

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Federal government websites often end in. The site is secure. General Flores , Montevideo , Uruguay. In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. In addition, peroxynitrite anion can secondarily evolve to secondary radicals either via its fast reaction with CO 2 or through proton-catalyzed homolysis.

Peroxynitrite

In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. In addition, peroxynitrite anion can secondarily evolve to secondary radicals either via its fast reaction with CO 2 or through proton-catalyzed homolysis. Peroxynitrite can cause protein tyrosine nitration in vitro and in vivo.

J org chem

Scott; Sagan, Elisabeth S. Gryglewski R. The last three listed compounds are examples of synthetic molecules utilized to either decompose or detect peroxynitrite. Uric acid is also a physiological substrate of myeloperoxidase 98 and may therefore interfere in heme peroxidase-dependent nitration reactions as well. S; Koppenol, W. MacMillan-Crow L. Notably, it has just been reported that nitration of Hsp90 plays a central role in motor neuron death through activation of the Fas pathway It isomerizes peroxynitrite to nitrate PMID Tools Tools. Masumoto H. For example, peroxynitrite-mediated oxidation of mitochondrial membrane components facilitates the release of pro-apoptotic factors, whereas poly ADP-ribose polymerase activation secondary to DNA oxidative damage triggers necrosis Ischiropoulos H. Franco M.

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The reactions of peroxynitrite with biomolecules can led to cytotoxic events, which may result in apoptotic or necrotic cell death 54 , 70 , Lymar S. Therefore, its direct toxicity is usually limited i. Isomerization to nitrate and secondary formation of protein radicals. This reaction is relevant because of the ubiquity of CO 2 in biological systems e. It also yields secondary free radical intermediates such as nitrogen dioxide and carbonate radicals. Redondo-Horcajo M. Beckmann J. Some answers to the cardinal questions in nitric oxide biology. Mn-porphyrins MnP. The site is secure. E-mail: yu.