Quinoxaline

Quinoxaline C8H6N2commonly called quinoxaline, 1,4-benzodiazine, quinoxaline, or benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene quinoxaline fused with the pyrazine ring. A number of different methods for the synthesis of quinoxaline derivatives have been reported in the literature, but the most effective method, quinoxaline, commonly used for the quinoxaline of quinoxaline analogues involves the condensation of substituted o-phenylenediamines with 1, 2- dicarbonyl compounds in the presence of different catalyst s. The presence of different types of catalysts and their concentration affects the overall yield of the product. Quinoxaline not only plays an important role as an organic reaction intermediate but also has a wide spectrum of interesting biological activities viz.

A quinoxaline , also called a benzopyrazine , in organic chemistry , is a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring. It is isomeric with other naphthyridines including quinazoline , phthalazine and cinnoline. Although quinoxaline itself is mainly of academic interest, quinoxaline derivatives are used as dyes, pharmaceuticals such as varenicline , and antibiotics such as olaquindox , carbadox , echinomycin , levomycin and actinoleutin. They can be formed by condensing ortho - diamines with 1,2- diketones. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. One study [6] used 2-iodoxybenzoic acid IBX as a catalyst in the reaction of benzil with 1,2-diaminobenzene:. The antitumoral properties of quinoxaline compounds have been of interest.

Quinoxaline

Bioinspired ortho -quinone catalysts have been applied to oxidative synthesis of benzimidazoles, quinoxalines and benzoxazoles from primary amines in high yields under mild conditions with oxygen as the terminal oxidant. Zhang, Y. Qin, L. Zhang, S. Luo, Org. Bains, V. Singh, D. Adhikari, J. Shee, D. Panja, S. Kundu, J. Aerobic oxidation of deoxybenzoins is efficiently catalyzed by 1,4-diazabicyclo[2. The process has been successfully extended to a one-pot synthesis of quinoxalines from benzyl ketones and aromatic 1,2-diamines. Qi, H. Jiang, L.

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Quinoxaline has become a subject of extensive research due to its emergence as an important chemical moiety, demonstrating a wide range of physicochemical and biological activities. The last few decades have witnessed several publications utilizing quinoxaline scaffolds for the design and development of numerous bioactive molecules, dyes, fluorescent materials, electroluminescent materials and organic sensitizers for solar cell applications and polymeric optoelectronic materials. Therefore, to fulfill the need of the scientific community, tremendous effort has been observed in the development of newer synthetic strategies as well as novel methodologies to decorate the quinoxaline scaffold with proper functional groups. Hence, to provide an updated comprehensive account of the diverse synthetic routes to access quinoxaline as well as approaches for structural diversifications, we have attempted to document the synthetic strategies and their functionalization with possible mechanistic rationalization. This will no doubt be helpful for the readers who are anticipating a comprehensive overview on quinoxaline as well as benefitting researchers for future development.

Quinoxaline

Federal government websites often end in. The site is secure. Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties antiviral, anticancer, and antileishmanial , ensuring them a bright future in medicinal chemistry. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.

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A number of different methods for the synthesis of quinoxaline derivatives have been reported in the literature, but the most effective method, commonly used for the synthesis of quinoxaline analogues involves the condensation of substituted o-phenylenediamines with 1, 2- dicarbonyl compounds in the presence of different catalyst s. Hazard statements. Tools Tools. Cho, K. Yuan, K. This paper describes the preparation of quinoxaline as an intermediate. Bhilare, N. Y verify what is Y N? Lin, Z. PubChem CID. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Quinoxaline C8H6N2 , commonly called 1,4-diazanaphthalene, 1,4-benzodiazine, or benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene ring fused with the pyrazine ring. Bao, M.

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Cheng, X. Interactive image. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Baude, E. ISBN Zhang, S. Download as PDF Printable version. A large number of quinoxaline analogues possessing different biological activities and their synthetic procedures have been patented worldwide. Determination of Organic Structures by Physical Methods. Chen, X. Li, Y. Chen, Y. Jones and Keith C.