Reticulocyte production index formula

Determines the reticulocyte index production RPI based on reticulocyte count, hematocrit or hemoglobin through two different methods.

The reticulocyte production index RPI , also called a corrected reticulocyte count CRC , is a calculated value used in the diagnosis of anemia. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The problem arises because the reticulocyte count is not really a count but rather a percentage : it reports the number of reticulocytes as a percentage of the number of red blood cells. In anemia, the patient's red blood cells are depleted, creating an erroneously elevated reticulocyte count. Reticulocytes are newly produced red blood cells. They are slightly larger than totally mature red blood cells, and have some residual ribosomal RNA. The presence of RNA allows a visible blue stain to bind or, in the case of fluorescent dye, result in a different brightness.

Reticulocyte production index formula

The Reticulocyte production index RPI, also called a corrected reticulocyte count is a calculated value used in the diagnosis of anemia. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The problem arises because the reticulocyte count is not really a count but rather a percentage: it reports the number of reticulocytes as a percentage of the number of red blood cells. In anemia, the patient's red blood cells are depleted, creating an erroneously elevated reticulocyte count. Source: Wikipedia. They develop and mature in the bone marrow and then circulate for about a day in the blood before developing into mature RBC. Like mature RBC, reticulocytes do not have a nucleus. They are called reticulocytes because of a reticular mesh-like network of ribosomal RNA that is visible under a microscope. Reticulocytes appear slightly bluer than other RBC when stained with Romanowsky stain. Reticulocytes are also slightly larger and thus can be identified as a high mean corpuscular volume during a full blood count done by machine. Source: Wikipedia, Reticulocytes Wikipedia. LP Reticulocytes In humans, reticulocytes are erythroid cells that have just undergone extrusion of their nucleus. They still contain some organelles that gradually decrease in number as the cells mature. Ribosomes are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" not the same as the endoplasmic retuculum , hence the name reticulocytes.

Hematology blood tests.

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Determines the reticulocyte index production RPI based on reticulocyte count, hematocrit or hemoglobin through two different methods. In the text below the calculator there is more information on the two determination methods and an RPI interpretation. The reticulocyte index uses the percentage of immature red blood cells and either haemoglobin or haematocrit to determine the reticulocyte production index. This can offer complete information about the composition of RBCs in terms of cells at all stages of maturation. RPI is used in assessing the response to anemia, especially in patients diagnosed with Sickle Cell disease. Reticulocyte production index explained. To embed this calculator, please copy this code and insert it into your desired page:. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.

Reticulocyte production index formula

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To embed this calculator, please copy this code and insert it into your desired page:. They develop and mature in the bone marrow and then circulate for about a day in the blood before developing into mature RBC. Retrieved Tools Tools. Next Review: June 7, This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The Reticulocyte production index RPI, also called a corrected reticulocyte count is a calculated value used in the diagnosis of anemia. Hematology blood tests. Reticulocytes are also slightly larger and thus can be identified as a high mean corpuscular volume during a full blood count done by machine. Abbreviation: RPI. Hillman, et al. Blood film Blood viscosity Nitro blue tetrazolium chloride test Flow cytometry Immunophenotyping. Other Tools Feedback How to Print. Calculated value in diagnosis of anemia.

The reticulocyte production index RPI , also called a corrected reticulocyte count CRC , is a calculated value used in the diagnosis of anemia. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The problem arises because the reticulocyte count is not really a count but rather a percentage : it reports the number of reticulocytes as a percentage of the number of red blood cells.

Reticulocyte Index. Year Of Study: Reticulocytes are also slightly larger and thus can be identified as a high mean corpuscular volume during a full blood count done by machine. Reticulocytes appear slightly bluer than other RBC when stained with Romanowsky stain. LP Reticulocytes In humans, reticulocytes are erythroid cells that have just undergone extrusion of their nucleus. Archived from the original on Normal RPI varies between 0. Values greater than 3, when accompanied by anemia, indicate RBC loss but an increased production of reticulocytes. Marrow defects include nutritional deficiencies i. RPI interpretation 4. Article Talk. All Rights Reserved.