Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root".

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals.

Salvia miltiorrhiza

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. Salvia miltiorrhiza Bunge, also known as red sage or Danshen Chinese Pinyin name , is a perennial plant Fig.

Danshen salvia miltiorrhiza enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Ischemic cardiovascular disease 74 1 month.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs.

Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B , [3] [4] dihydrotanshinone , miltirone , [5] tanshinone I , and tanshinone IIA. The 30 cm 0. Flowers grow in whorls, with light purple to lavender blue corollas that are approximately 2. Salvia miltiorrhiza prefers well-drained soil, with about half a day of sunlight. Danshen may potentiate the effects of the anticoagulation drug warfarin , possibly causing bleeding complications. Alone or combined with other Chinese herbal medicines, Salvia miltiorrhiza has been used in China and, to a lesser extent, in other countries as a treatment for various cardiovascular and cerebrovascular diseases. Contents move to sidebar hide. Article Talk.

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Co-administration of Danshen and warfarin should be avoided or closely monitored [ 54 ]. Ineffective: No improvement in clinical symptoms, ECG and myocardial enzymes. Ann Pharmacother. Sun Q. Primary efficacy: Carotid intima-media thickness decreased. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. J Cereb Blood Flow Metab. Ling S. Recovery 18 Markedly improved Further, ET-1 is a vasoconstricting peptide produced primarily in the endothelium which contributes to constrict blood vessels and raise blood pressure. In other projects. Publication types Research Support, Non-U.

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Recovery 18 Markedly improved Significant effect: Clinical symptoms completely or almost disappeared; ECG completely or almost returned to normal; Blood lipid levels returned to normal. Effective: Clinical symptoms decreased; Cardiac function increased by more than 1 level. Ineffective: No improvement in clinical symptoms or even worse. NO plays the cardioprotective role through regualting blood pressure and vascular tone, and inhibiting platelet aggregation and leukocyte adhesion as well as preventing smooth muscle cell proliferation. As a library, NLM provides access to scientific literature. Observation of yindan xinnaotong capsule for treatment of coronary heart disease angina pectoris 50 cases. The observations from the clinical trials have demonstrated that S. But the mechanisms remain unclear. Inflammation, endothelial dysfunction and arterial stiffness as therapeutic targets in cardiovascular medicine. The intrarenal renin-angiotensin system in hypertension. The Annals of Pharmacotherapy. The results strongly support the notion that S. Clinical observation of the effective of Tongxinluo capsule on angina pectoris in patients with coronary heart disease. Meanwhile, increased MMP-2 activity potentiates inflammation insults and plaque instability in the injured vascular wall [ ].