Alpha inhibin

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Check out our latest pathology themed Wordle here! Updated every Monday. Editorial Board Member: Christian M. Page views in 13, Cite this page: Wirth P.

Alpha inhibin

Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Normal testis or normal ovary, adrenal gland. Groome, N G et al Monoclonal and polyclonal antibodies reactive with the amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9 1 : 2. Groome, N G et al Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen. Hybridoma 10 2 : 3. Journal of Pathology 4. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol May;53 5 5. Center for Disease Control Manual.

INHA protein expression alpha inhibin generally considered an important diagnostic feature for adrenocortical tumors and granular cell tumors, as well as sex cord stromal tumors of the testis and the ovary [ 28373839 ], alpha inhibin. Data Availability Statement All data generated or analyzed during this study are included in this published article. It combines with the A and B type proteins of the inhibin beta subunits to form inhibin protein complexes that negatively regulate the secretion of follicle-stimulating hormone FSH from the pituitary gland [ 456 ].

It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male.

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

Alpha inhibin

Check out our latest pathology themed Wordle here! Updated every Monday. Editorial Board Member: Christian M. Page views in 13, Cite this page: Wirth P. Accessed March 7th, Dimeric glycoprotein consisting of alpha and beta subunits that is mainly produced in the gonads Regulates follicle stimulating hormone FSH secretion through negative feedback mechanisms with paracrine and autocrine actions on gonads and adrenal glands. Essential features.

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These especially included multiple cases of acinar cell carcinoma of the pancreas. Tissue microarrays for high-throughput molecular profiling of tumor specimens. The inhibin alpha subunit protein INHA is a member of the TGF-beta transforming growth factor-beta superfamily encoded by a gene located at 2q35 [ 1 , 2 , 3 ]. Non-interpretable samples demonstrated a lack of unequivocal tumor cells or loss of the tissue spot during technical procedures. This site uses Akismet to reduce spam. Clone: R1. Microscopic histologic description. Successfully added to cart added to cart. Your order will be processed as normal and may take additional days to ship. Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. To ensure as broad as possible a range of proteins to be tested for possible cross-reactivity, 76 different normal tissue categories were included in this analysis. It is expected that different experimental conditions could change the INHA positivity rates—especially in tumors with low expression levels—but this would have little impact on the tumor ranking based on the INHA positivity rates.

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Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Uses by pathologists. Non-invasive papillary urothelial carcinoma, pTa G2 high grade. Mouse Monoclonal. Anti-alpha-inhibin: Marker of choice for the consistent distinction between adrenocortical carcinoma and renal cell carcinoma in fine-needle aspiration. Introduction The inhibin alpha subunit protein INHA is a member of the TGF-beta transforming growth factor-beta superfamily encoded by a gene located at 2q35 [ 1 , 2 , 3 ]. A comparison of A and inhibin reactivity in adrenal cortical tumors: Distinction from hepatocellular carcinoma and renal tumors. Inhibin belongs to the transforming growth factor-beta TGF-beta family. The arrayed cancer samples were mainly of Caucasian origin and underwent surgery at the University Medical Center Hamburg-Eppendorf between and However, other tumors can also express INHA.