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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on euronetwork nervous system.

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies.

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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms. Paraneoplastic neurologic syndrome PNS can affect any part of the nervous system. Rarely, they are seen in the course of an oncologic disease. Survival is usually influenced by the oncologic disease, but PNS can cause severe disability and may be fatal. The lack of extensive clinical and epidemiologic studies on these rare disorders prompted establishment of the PNS Euronetwork by 20 consortium members from 11 European countries. Between January 1, , and December 31, , the partnership collected information on patients, resulting in the largest database on PNS to date.

Outcome status was available in patients Next statement date 14 December euronetwork by 28 December The database included the 'classical' PNS plus several others, euronetwork, less-well characterised syndromes in association with cancer.

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Tell us what you think of this service link opens a new window Is there anything wrong with this page? Limbic encephalitis was associated with other syndromes in 49 patients. Purchase access. The clinical characteristics of the individual syndromes were recorded, permitting a descriptive analysis of clinical findings. Survival curves were computed using the Kaplan-Meier method and were compared using the log-rank test. Arch Neurol. Anti-Hu—associated paraneoplastic encephalomyelitis: analysis of patients. A substantial proportion of patients had chorea associated with their tumor, suggesting that this disorder could be considered a type of PNS. Paraneoplastic neurologic syndrome PNS can affect any part of the nervous system. The database was organized in the following 6 main areas: 1 basic patient data, including clinical syndrome and time of symptom onset and diagnosis; 2 laboratory data, including serum and cerebrospinal fluid antibodies and their detection methods; 3 treatment of the neurologic disease and cancer therapy; 4 diagnostic tests, including cerebrospinal fluid analysis, nerve conduction velocities, electromyography, and computed tomography and magnetic resonance imaging brain and spinal ; 5 list of the main types of PNS-related tumors; and 6 cause of death and the availability of autopsy material. Levine SM Cancer and myositis: new insights into an old association.

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system.

None of these patients had Hu antibodies. The database included the 'classical' PNS plus several others, less-well characterised syndromes in association with cancer. Outcomes of patients with pns and causes of death. Among the cohort, 1 tumor was found in patients, 2 tumors in 53 patients, and 0 tumors in patients. Results Data from patients were analyzed, representing the largest PNS investigation to date. All participating centers enrolled their patients according to the Graus criteria between January 1, , and December 31, The clinical profile of collected syndromes in our study confirms the results of previous studies 9 - 14 but is based on a much larger case series. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Conclusion: The study results confirm that PNS influences oncologic patient survival. The relative distribution of disorders confirms cerebellar degeneration and SN as the most frequently appearing types of PNS.