Sitagliptin maximum dose per day

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Objective: In clinical trials, the degree of glucose lowering with sitagliptin has been correlated with the magnitude of dipeptidyl peptidase-4 DPP-4 inhibition over 24 h. However, sitagliptin mg once daily provided numerically greater percent plasma DPP-4 inhibition compared with mg once daily. The purpose of this study was to evaluate whether sitagliptin mg once daily provides greater improvement in glycemic efficacy as assessed by weighted mean glucose WMG over 24 h relative to sitagliptin mg once daily and to relate the percent DPP-4 inhibition achieved with these doses to any between-treatment differences in glycemic efficacy. Each of the treatment periods was 7 days in duration, with day washout periods between treatments. After each treatment period, patients underwent blood sampling at various time points over 24 h to determine h WMG. Plasma DPP-4 activity was assessed at trough, 24 h following dosing on day 7; percent DPP-4 inhibition was corrected for sample assay dilution.

Sitagliptin maximum dose per day

Januvia sitagliptin is a prescription brand-name medication. The Food and Drug Administration FDA has approved it to treat type 2 diabetes in adults, in combination with exercise and a balanced diet. Januvia is available as a generic medication called sitagliptin. Sitagliptin is the active drug in Januvia. For information about the dosage of Januvia, including its form, strengths, and how to take the drug, keep reading. For a comprehensive look at Januvia, see this article. When taking Januvia, always follow the dosage prescribed by your doctor. The following information describes Januvia doses that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. The recommended dosage of Januvia for treating type 2 diabetes is mg once daily. Note: People with kidney problems may need a lower dosage of Januvia than usual.

The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Metformin and sitagliptin combination should be taken with meals to help reduce any stomach upset.

Back to Sitagliptin. Your doctor might prescribe a lower dose of 25mg or 50mg a day if you have problems with your kidneys. Take sitagliptin once a day. You can take it at any time, for example, in the morning or in the evening. But try to take it at the same time every day.

Sitagliptin maximum dose per day

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Exercise regularly and test for sugar in your blood or urine as directed.

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Januvia dosage. Mayo Clinic does not endorse companies or products. Levemir is a prescription drug used to treat type 1 and type 2 diabetes. Health Information Policy. This content does not have an English version. Do not stop taking this medicine without checking first with your doctor. International Business Collaborations. Mayo Clinic does not endorse companies or products. These additional articles might be helpful to you:. Refer a Patient. Take the extended-release tablets as directed in the evening. If your dose is different, do not change it unless your doctor tells you to do so. Help us advance cardiovascular medicine. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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Products and services. Note: Januvia contains the active drug sitagliptin. If you have questions about using Januvia and metformin together, talk with your doctor or pharmacist. Financial Services. Thank you for subscribing! Do not double doses. Help us advance cardiovascular medicine. This medicine should come with a Medication Guide. Read and follow these instructions carefully. If you are a Mayo Clinic patient, this could include protected health information. Community Health Needs Assessment.