Dipali sharma

Bride-to-be Kriti Kharbanda flaunts her girl-next-door style in strappy blue midi dress, apt for Summer.

Unveiling the molecular links between obesity, the microbiome, and breast cancer and developing strategies to disrupt them. Obesity is an important risk factor for breast cancer—a five-unit increase in BMI is associated with a 12 percent increase in breast cancer risk. In the United States, about 36 percent of adults are obese based on BMI, while approximately 13 percent of the world population is obese, and the prevalence is increasing globally. Sharma and her team study the molecular changes induced by obesity that promote breast cancer development, progression, and metastasis. They also focus on the intersections between obesity and the microbiome the bacteria that reside throughout our body. Many studies found that the complex makeup of the microbiome changes with disease or other alterations to our physiology—like fluctuations in weight—and these changes in bacterial populations may have profound effects on the body. They also found that high leptin levels hyperleptinemia associated with obese state is a major factor in breast cancer growth, metastasis and in cancer initiation.

Dipali sharma

Areas of specific interest include understanding the molecular connections between breast cancer and obesity, racial disparities, and microbial dysbiosis. Obesity is an important risk factor for breast cancer—a 5-unit increase in BMI is associated with a 12 percent increase in breast cancer risk. In the United States, about 36 percent of adults are obese, and the prevalence is increasing globally. We are uncovering new pathways as well as developing strategies to abrogate obesity-breast cancer axis and improving therapeutic response in obese women. Racial disparity in breast cancer is clearly evident in triple negative breast cancer TNBC with younger African American women exhibiting a disproportionately higher burden of TNBC, an aggressive subtype of breast cancer. The Sharma lab is working to understand the molecular wiring and examining novel drug combinations for African American women with TNBC. Microbial eubiosis and dysbiosis are of growing interest as we now appreciate that the number of microbial cells living within and on human body is roughly equal to the total number of human cells. While eubiosis is associated with normal functioning of the body, dysbiosis can impact disease progression as well as response to therapy. The Sharma lab has uncovered that a pro-oncogenic colon microbe potentiates breast cancer initiation and progression. Current projects aim to understand the mechanistic links between microbiota and breast cancer and develop strategies to harness bugs to modulate the response to drugs. Cancer Discovery,

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Areas of specific interest include understanding the molecular connections between breast cancer and obesity, racial disparities, and microbial dysbiosis. Obesity is an important risk factor for breast cancer—a 5-unit increase in BMI is associated with a 12 percent increase in breast cancer risk. In the United States, about 36 percent of adults are obese, and the prevalence is increasing globally. We are uncovering new pathways as well as developing strategies to abrogate obesity-breast cancer axis and improving therapeutic response in obese women. Racial disparity in breast cancer is clearly evident in triple negative breast cancer TNBC with younger African American women exhibiting a disproportionately higher burden of TNBC, an aggressive subtype of breast cancer.

Dipali sharma

Deepali Sawai is a Computer Engineer and is the alumnus of Janana Probodhini Prashala, a school formed for gifted students. ISBN No. Computer Champs series for Std. For maintaining the quality of the Institutes, she has published the process Manual depicting and explaining all the processes taking place in the Institutes under ATSS. She has presented and published several papers in National , International conferences and reputed indexed journals.

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Aqsa Akbani Siddiqui, a BMM graduate with a specialization in Journalism, boasts an impressive and diverse career spanning. Katrina Kaif aces old-school charm of polka-dotted dress in airport look; pairs it with oversized jacket. She sees a mysterious person in a black hoodie and freaks out. You May Like This 1. Latest Articles tv. All hell breaks loose when Aradhna learns that Reyansh is no more. Bride-to-be Kriti Kharbanda flaunts her girl-next-door style in strappy blue midi dress, apt for Summer. Today is the first day of the shoot. When not working, Aqsa loves spending time with her family. She has also done a few projects in the Telgu entertainment industry. Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR and ErbB. Elife, Her studies on obesity-related hormones, adipocytokines, showed that leptin promotes the proliferative response and metastatic potential as well as modulates the expression of various genes involved in cell cycle, apoptosis and metastasis.

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Nature Partner Journals Breast Cancer, Cancer Discovery, Oscars After-party The Kardashians personify hotness in statement-worthy couture gowns. Clear Search. In the United States, about 36 percent of adults are obese based on BMI, while approximately 13 percent of the world population is obese, and the prevalence is increasing globally. Research area Unveiling the molecular links between obesity, the microbiome, and breast cancer and developing strategies to disrupt them. The core concept of the show was falling in love despite red flags. Her entry is set to cause a major twist in Ardhana-Reyaansh's relationship. Get The Latest. Subscribe to our newsletter for entertainment exclusives, star interviews, and the latest lifestyle trends. You May Like This tv.